Article
Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice.
Experimental eye research - 1 Oct 2015
Bonilha Vera L, Bell Brent A, Rayborn Mary E, Yang Xiaoping, Kaul Charlie, Grossman Gregory H, Samuels Ivy S, Hollyfield Joe G, Xie Chengsong, Cai Huaibin, Shadrach Karen G
Abstract excerpt
DJ-1/PARK7 mutations or deletions cause autosomal recessive early onset Parkinson's disease (PD). Thus, DJ-1 protein has been extensively studied in brain and neurons. PD patients display visual symptoms; however, the visual symptoms specifically attributed to PD patients carrying DJ-1/PARK7 mutations are not known. In this study, we analyzed the structure and physiology of retinas of 3- and 6-month-old DJ-1...
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