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Article

ER Stress and Mitochondrial Perturbations Regulate Cell Death in Retinal Detachment: Exploring the Role of HIF1α

26 Sept 2024

Abstract excerpt

Purpose: Retinal detachment (RD) leads to photoreceptor (PR) hypoxia due to separation from the retinal pigment epithelium (RPE). Hypoxia stabilizes retinal hypoxia-inducible factor 1-alpha (HIF1α), crucial for PR survival during RD. This study explores the regulatory role of HIF1α in PR cell survival pathways during RD. Methods: Experimental RD was created in C57BL/6J and HIF1αΔrod mice by injecting 1%...

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PMID: 39325470
DOI: 10.1167/iovs.65.11.39

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