Article
Evidence for two apoptotic pathways in light-induced retinal degeneration.
Nature genetics - 1 Oct 2002
Hao Wenshan, Wenzel Andreas, Obin Martin S, Chen Ching-Kang, Brill Elliott, Krasnoperova Nataliia V, Eversole-Cire Pamela, Kleyner Yelena, Taylor Allen, Simon Melvin I, Grimm Christian, Remé Charlotte E, Lem Janis
Abstract excerpt
Excessive phototransduction signaling is thought to be involved in light-induced and inherited retinal degeneration. Using knockout mice with defects in rhodopsin shut-off and transducin signaling, we show that two different pathways of photoreceptor-cell apoptosis are induced by light. Bright light induces apoptosis that is independent of transducin and accompanied by induction of the transcription factor AP-1....
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