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Article

NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes.

Journal of virology - 1 Jul 2011

Paul David, Romero-Brey Inés, Gouttenoire Jérôme, Stoitsova Savina, Krijnse-Locker Jacomine, Moradpour Darius, Bartenschlager Ralf

Abstract excerpt

Hepatitis C virus (HCV) is an important human pathogen, persistently infecting more than 170 million individuals worldwide. Studies of the HCV life cycle have become possible with the development of cell culture systems supporting the replication of viral RNA and the production of infectious virus. However, the exact functions of individual proteins, especially of nonstructural protein 4B (NS4B), remain poorly...

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Identifiers

PMID: 21543474
DOI: 10.1128/JVI.00502-11
PMCID: PMC3126587

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Source receipt: pubmed, retrieved 7 Sept 2026.

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