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Article

Allelic variation in the hepatitis C virus NS4B protein dramatically influences RNA replication.

Journal of virology - 1 Jun 2007

Blight Keril J

Abstract excerpt

In the Huh-7.5 hepatoma cell line, replication of the genotype 1a H77 strain of hepatitis C virus (HCV) is attenuated compared to that of the genotype 1b Con1 strain. This study identifies the poorly characterized integral membrane protein, NS4B, as a major determinant for this replication difference. Chimeric H77 subgenomic replicons containing the entire NS4B gene from Con1 in place of the H77 NS4B sequence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Molecular Sequence Data

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Source

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Identifiers

PMID: 17360748
DOI: 10.1128/JVI.02481-06
PMCID: PMC1900245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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