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Article

The feedback loop between miR-21, PDCD4 and AP-1 functions as a driving force for renal fibrogenesis

20 Jan 2018

Abstract excerpt

Renal fibrosis is a final common pathway of chronic kidney disease. Sustained activation of fibroblasts is considered to play a key role in perpetuating renal fibrosis but the driving force in the perpetuation stage is only partially understood. To date, some investigations have specifically identified overexpression of microRNA 21 (miR-21) in the progression of kidney fibrosis. Nevertheless, the precise role of...

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PMID: 29361523
DOI: 10.1242/jcs.202317

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