Article
Evaluation of markers on human chromosome 10, including the homologue of the rodent Rf-1 gene, for linkage to ESRD in black patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Feb 1999
Yu H, Sale M, Rich S S, Spray B J, Roh B H, Bowden D W, Freedman B I
Abstract excerpt
There is abundant evidence supporting the contribution of genetic factors to the development of end-stage renal disease (ESRD) in blacks. Two renal failure susceptibility genes, Rf-1 and Rf-2, have been identified in the fawn-hooded rat, an animal model of hypertension and nephrosclerosis. The human homologous region containing the rodent Rf-1 gene has been localized to chromosome 10q. We tested for genetic...
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