Article
Axons guided by insulin receptor in Drosophila visual system.
Science (New York, N.Y.) - 18 Apr 2003
Song Jianbo, Wu Lingling, Chen Zun, Kohanski Ronald A, Pick Leslie
Abstract excerpt
Insulin receptors are abundant in the central nervous system, but their roles remain elusive. Here we show that the insulin receptor functions in axon guidance. The Drosophila insulin receptor (DInR) is required for photoreceptor-cell (R-cell) axons to find their way from the retina to the brain during development of the visual system. DInR functions as a guidance receptor for the adapter protein Dock/Nck. This...
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