Article
Annexin A5 haplotypes in familial hypercholesterolemia: lack of association with carotid intima-media thickness and cardiovascular disease risk.
Atherosclerosis - 1 Feb 2015
Hiddink Larissa, Dallinga-Thie Geesje M, Hovingh G Kees, de Visser Marieke C H, Peer Petronella G M, Stalenhoef Anton F H, van Heerde Waander L
Abstract excerpt
OBJECTIVE: Annexin A5 (ANXA5) has been suggested to possess antiatherogenic properties. We investigated whether ANXA5 genetic variations and plasma ANXA5 levels were associated with carotid atherosclerosis and contributed to cardiovascular disease (CVD) risk in patients with familial hypercholesterolemia (FH). METHODS: We sequenced the promoter region and exon 2 of ANXA5 in 284 FH patients from the ASAP...
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