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Article

Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2011

Nadkarni Suchita, Cooper Dianne, Brancaleone Vincenzo, Bena Stefania, Perretti Mauro

Abstract excerpt

OBJECTIVE: The anti-inflammatory properties of the female sex hormone estrogen have been linked to a reduced incidence of cardiovascular disease. In the present study, we addressed whether estrogen could activate vasculoprotective mechanisms via annexin A1 (AnxA1) mobilization in human polymorphonuclear cells (PMNs). METHODS AND RESULTS: Using whole-blood flow cytometry, we demonstrated that premenopausal women...

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Identifiers

PMID: 21836070
DOI: 10.1161/ATVBAHA.111.235176
PMCID: PMC3357483

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