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Article

The majority of animal genes are required for wild-type fitness.

Cell - 17 Feb 2012

Ramani Arun K, Chuluunbaatar Tungalag, Verster Adrian J, Na Hong, Vu Victoria, Pelte Nadège, Wannissorn Nattha, Jiao Alan, Fraser Andrew G

Abstract excerpt

Almost all eukaryotic genes are conserved, suggesting that they have essential functions. However, only a minority of genes have detectable loss-of-function phenotypes in experimental assays, and multiple theories have been proposed to explain this discrepancy. Here, we use RNA-mediated interference in C. elegans to examine how knockdown of any gene affects the overall fitness of worm populations. Whereas...

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PMID: 22341449
DOI: 10.1016/j.cell.2012.01.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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