Article
AMP-activated protein kinase β-subunit requires internal motion for optimal carbohydrate binding.
Biophysical journal - 18 Jan 2012
Bieri Michael, Mobbs Jesse I, Koay Ann, Louey Gavin, Mok Yee-Foong, Hatters Danny M, Park Jong-Tae, Park Kwan-Hwa, Neumann Dietbert, Stapleton David, Gooley Paul R
Abstract excerpt
AMP-activated protein kinase interacts with oligosaccharides and glycogen through the carbohydrate-binding module (CBM) containing the β-subunit, for which there are two isoforms (β(1) and β(2)). Muscle-specific β(2)-CBM, either as an isolated domain or in the intact enzyme, binds carbohydrates more tightly than the ubiquitous β(1)-CBM. Although residues that contact carbohydrate are strictly conserved, an...
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