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Article

Role of connecting loop I in catalysis and allosteric regulation of human glucokinase.

Protein science : a publication of the Protein Society - 1 Jul 2014

Martinez Juliana A, Larion Mioara, Conejo Maria S, Porter Carol M, Miller Brian G

Abstract excerpt

Glucokinase (GCK, hexokinase IV) is a monomeric enzyme with a single glucose binding site that displays steady-state kinetic cooperativity, a functional characteristic that affords allosteric regulation of GCK activity. Structural evidence suggests that connecting loop I, comprised of residues 47-71, facilitates cooperativity by dictating the rate and scope of motions between the large and small domains of GCK....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24723372
DOI: 10.1002/pro.2473
PMCID: PMC4088975

Genes

GCK

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