Article
The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor.
Cell metabolism - 7 Jan 2009
McBride Andrew, Ghilagaber Stephanos, Nikolaev Andrei, Hardie D Grahame
Abstract excerpt
AMPK beta subunits contain a conserved domain that causes association with glycogen. Although glycogen availability is known to affect AMPK regulation in vivo, the molecular mechanism for this has not been clear. We now show that AMPK is inhibited by glycogen, particularly preparations with high branching content. We synthesized a series of branched oligosaccharides and show that those with a single alpha1-->6...
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