Article

Tankyrase interacts with the allosteric site of glucokinase and inhibits its glucose-sensing function in the beta cell

2021-08-08

Abstract excerpt

<h4>ABSTRACT</h4> Insulin secretion in the pancreatic beta cell is rate-limited by glucokinase (GCK), the glucose sensor that catalyzes the first step of glucose metabolism. GCK consists of two lobes connected by a flexible hinge that allows the kinase to exhibit a spectrum of conformations ranging from the active, closed form to several inactive, less-compact forms. Activating GCK mutations can cause hyperinsuli...

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Literature Corpus work: 6ef15ee3-c172-5e36-b37e-887244832a07
DOI: 10.1101/2021.08.08.454510

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