Article
[Relationship of insulin-like growth factor receptor single nucleotide polymorphism (SNP) with platinum-based chemotherapy outcomes in advanced non-small cell lung cancer].
Zhongguo fei ai za zhi = Chinese journal of lung cancer - 1 Feb 2012
Chen Yusheng, Shao Hui, Li Hongru, Han Lili, Zhang Xiang'e
Abstract excerpt
BACKGROUND AND OBJECTIVE: It has been proven that the insulin-like growth factor 1 receptor (IGF-1R) gene is an important regulator of many aspects of growth, differentiation, and development. The insulin-like growth factor 2 receptor (IGF-2R) gene is a negative mediator for carcinogenesis. The aim of this study is to investigate the relationship of IGF-1R+1013(G/A) and IGF-2R+1619(G/A) single nucleotide...
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