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Article

The Clinical Significance of the Insulin-Like Growth Factor-1 Receptor Polymorphism in Non-Small-Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation.

International journal of molecular sciences - 18 May 2016

Liu Tu-Chen, Hsieh Ming-Ju, Liu Ming-Che, Chiang Whei-Ling, Tsao Thomas Chang-Yao, Yang Shun-Fa

Abstract excerpt

The insulin-like growth factor 1 (IGF1) signaling pathway mediates multiple cancer cell biological processes. IGF1 receptor (IGF1R) expression has been used as a reporter of the clinical significance of non-small-cell lung carcinoma (NSCLC). However, the association between IGF1R genetic variants and the clinical utility of NSCLC positive for epidermal growth factor receptor (EGFR) mutation is not clear. The...

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Source

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Identifiers

PMID: 27213344
DOI: 10.3390/ijms17050763
PMCID: PMC4881584

Genes

EGFR
IGF1

Variants

rs2229765

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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