Article
[Association of the responsiveness of advanced non-small cell lung cancer to platinum-based chemotherapy with p53 and p73 polymorphisms].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Feb 2006
Yuan Peng, Miao Xiao-ping, Zhang Xue-mei, Wang Zhong-hua, Tan Wen, Zhang Xiang-ru, Sun Yan, Xu Bing-he, Lin Dong-xin
Abstract excerpt
OBJECTIVE: It has been proposed that genetic polymorphisms in apoptosis-related genes might be associated with sensitivity of cancer cells to platinum-based chemotherapy. This study examined the relationship between p53 and p73 genetic polymorphisms and the response to platinum-based chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS: A total of 165 patients with advanced NSCLC...
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