Polymorphisms in DNA repair and apoptosis-related genes and clinical outcomes of patients with non-small cell lung cancer treated with first-line paclitaxel-cisplatin chemotherapy.

doi:10.1016/j.lungcan.2013.07.024

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Article

Polymorphisms in DNA repair and apoptosis-related genes and clinical outcomes of patients with non-small cell lung cancer treated with first-line paclitaxel-cisplatin chemotherapy.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2013

Lee Shin Yup, Kang Hyo-Gyoung, Yoo Seung Soo, Kang Ye Rim, Choi Yi Young, Lee Won Kee, Choi Jin Eun, Jeon Hyo-Sung, Shin Kyung Min, Oh In Jae, Kim Kyu Sik, Lee Jaehee, Cha Seung Ick, Kim Chang Ho, Kim Young Chul, Park Jae Yong

Abstract excerpt

This study was conducted to analyze a comprehensive panel of single nucleotide polymorphisms (SNPs) in genes in DNA repair and apoptosis pathways and determine the relationship between polymorphisms and treatment outcomes of patients with non-small cell lung cancer (NSCLC) treated with first-line paclitaxel-cisplatin chemotherapy. Three hundred eighty two patients with NSCLC were enrolled. Seventy-four SNPs in 48...

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Identifiers

PMID: 23973201
DOI: 10.1016/j.lungcan.2013.07.024

Genes

BCL2
BRCA1
CASP8
ERCC2
XRCC1

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