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Article

Polymorphisms of BCL2 and BAX Genes Associate with Outcomes in Advanced Non-small cell lung cancer Patients treated with platinum-based Chemotherapy.

Scientific reports - 10 Dec 2015

Peng Yu, Wang Linang, Qing Yi, Li Chongyi, Ren Tao, Li Qing, Li Mengxia, Zhang Shiheng, Shan Jinglu, Wang Ge, Yang Zhenzhou, Wang Dong

Abstract excerpt

Single-nucleotide polymorphisms (SNP) of the gene belonging to the BCL2 family are thought to play a role in chemotherapy resistance. This study investigated the association of BCL2-938C>A(rs2279115) and BAX-248G>A(rs4645878) promoter region SNPs and the clinical responses and outcomes of 235 non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. The data suggested that BAX-248GA...

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Identifiers

PMID: 26656462
DOI: 10.1038/srep17766
PMCID: PMC4674711

Genes

BAX
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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