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Article

Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer.

Molecular carcinogenesis - 1 Dec 2013

Liu Li, Wu Jing, Zhong Rong, Wu Chen, Zou Li, Yang Beifang, Chen Wei, Zhu Beibei, Duan Shengyu, Yu Dianke, Tan Wen, Nie Shaofa, Lin Dongxin, Miao Xiaoping

Abstract excerpt

Polymorphisms in DNA repair and apoptotic pathways may cause variations in chemosensitivity of non-small-cell lung cancer (NSCLC) through complex gene-gene and gene-environment interactions. A total of 200 advanced NSCLC patients who received platinum-based chemotherapies were recruited. The short-term clinical outcomes were classified as chemosensitive group, including complete remission (CR) and partial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22821704
DOI: 10.1002/mc.21942

Genes

XRCC1
FAS
XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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