Article
Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort.
Immunogenetics - 1 Apr 2006
Do Hervé, Vasilescu Alexandre, Diop Gora, Hirtzig Thomas, Coulonges Cédric, Labib Taoufik, Heath Simon C, Spadoni Jean-Louis, Therwath Amu, Lathrop Mark, Matsuda Fumihiko, Zagury Jean-François
Abstract excerpt
We have performed an extensive analysis of Th1/Th2 cytokine receptors IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFNgammaR1 gene polymorphisms to evaluate their impact on AIDS progression. The coding regions and promoters of these genes were sequenced in the genetics of resistance to immunodeficiency virus cohort, composed of 327 HIV-1-positive patients with extreme progression phenotypes, slow and rapid progressors,...
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