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Article

IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection.

Frontiers in immunology - 1 Jan 2022

Han Fei, Gulam Muhammad Yaaseen, Zheng Yichao, Zulhaimi Nurul Syuhada, Sia Wan Rong, He Dan, Ho Amanda, Hadadi Leila, Liu Zhenyu, Qin Peiwu, Lobie Peter E, Kamarulzaman Adeeba, Wang Lin-Fa, Sandberg Johan K, Lewin Sharon R, Rajasuriar Reena, Leeansyah Edwin

Abstract excerpt

MAIT cells are persistently depleted and functionally exhausted in HIV-1-infected patients despite long-term combination antiretroviral therapy (cART). IL-7 treatment supports MAIT cell reconstitution in vivo HIV-1-infected individuals and rescues their functionality in vitro. Single-nucleotide polymorphisms (SNPs) of the IL-7RA gene modulate the levels of soluble(s)IL-7Rα (sCD127) levels and influence...

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Identifiers

PMID: 36341446
DOI: 10.3389/fimmu.2022.985385
PMCID: PMC9632172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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