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IKZF3 amplification frequently occurs in HER2-positive breast cancer and is a potential therapeutic target.

Medical oncology (Northwood, London, England) - 30 Sept 2022

Lin Chih-Yi, Yu Chung-Jen, Shen Chia-I, Liu Chun-Yu, Chao Ta-Chung, Huang Chi-Cheng, Tseng Ling-Ming, Lai Jiun-I

Abstract excerpt

Breast cancer is one of the leading causes of cancer death in women, and although treatment outcome has substantially improved in the past decades, advanced or metastatic breast cancers still carry a poor prognosis. Gene amplification is one of the frequent genetic alterations in cancer, and oncogene amplification may be associated with cancer aggressiveness and oncogenicity. Targeting amplified genes such as...

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PMID: 36180600
DOI: 10.1007/s12032-022-01812-x

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