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Article

The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation.

Blood - 29 Mar 2012

Walasek Marta A, Bystrykh Leonid, van den Boom Vincent, Olthof Sandra, Ausema Albertina, Ritsema Martha, Huls Gerwin, de Haan Gerald, van Os Ronald

Abstract excerpt

Despite increasing knowledge on the regulation of hematopoietic stem/progenitor cell (HSPC) self-renewal and differentiation, in vitro control of stem cell fate decisions has been difficult. The ability to inhibit HSPC commitment in culture may be of benefit to cell therapy protocols. Small molecules can serve as tools to manipulate cell fate decisions. Here, we tested 2 small molecules, valproic acid (VPA) and...

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Identifiers

PMID: 22327222
DOI: 10.1182/blood-2011-08-375386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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