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Article

Expansion and preservation of the functional activity of adult hematopoietic stem cells cultured ex vivo with a histone deacetylase inhibitor.

Stem cells translational medicine - 1 Apr 2020

Zimran Eran, Papa Luena, Djedaini Mansour, Patel Ami, Iancu-Rubin Camelia, Hoffman Ronald

Abstract excerpt

Attempts to expand ex vivo the numbers of human hematopoietic stem cells (HSCs) without compromising their marrow repopulating capacity and their ability to establish multilineage hematopoiesis has been the subject of intense investigation. Although most such efforts have focused on cord blood HSCs, few have been applied to adult HSCs, a more clinically relevant HSC source for gene modification. To date, the...

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Identifiers

PMID: 31950644
DOI: 10.1002/sctm.19-0199
PMCID: PMC7103619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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