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Article

Prediction of methotrexate clinical response in Portuguese rheumatoid arthritis patients: implication of MTHFR rs1801133 and ATIC rs4673993 polymorphisms.

BioMed research international - 1 Jan 2014

Lima Aurea, Monteiro Joaquim, Bernardes Miguel, Sousa Hugo, Azevedo Rita, Seabra Vitor, Medeiros Rui

Abstract excerpt

OBJECTIVE: Methotrexate (MTX), the most used drug in rheumatoid arthritis (RA) treatment, showing variability in clinical response, is often associated with genetic polymorphisms. This study aimed to elucidate the role of methylenetetrahydrofolate reductase (MTHFR) C677T and aminoimidazole carboxamide adenosine ribonucleotide transformylase (ATIC) T675C polymorphisms and clinicopathological variables in clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24967362
DOI: 10.1155/2014/368681
PMCID: PMC4055378

Genes

ATIC
MTHFR

Variants

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