Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuroprotective role of the TREK-1 channel in decompression sickness.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Apr 2012

Vallee Nicolas, Meckler Cédric, Risso Jean-Jacques, Blatteau Jean-Eric

Abstract excerpt

Nitrogen supersaturation and bubble formation can occur in the vascular system after diving, leading to death and nervous disorders from decompression sickness (DCS). Bubbles alter the vascular endothelium, activate platelets, and lead to focal ischemia with neurological damage mediated by the mechanosensitive TREK-1 neuronal potassium ion channel that sets pre- and postsynaptic resting membrane potentials. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Forelimb
Share to Hand Strength

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocyte Count

Share to Muscle Contraction

Share to Neuroprotective Agents

Share to Platelet Count

Share to Potassium Channels, Tandem Pore Domain

Source

Identifiers

PMID: 22323654
DOI: 10.1152/japplphysiol.01100.2011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuroprotective role of the TREK-1 channel in decompression sickness.PMID 22323654Read ↗

Intracellular activation of full-length human TREK-1 channel by hypoxia, high lactate, and low pH denotes polymodal integration by ischemic factors.Semantic proximity Read ↗

Genetic susceptibility to decompression sickness: molecular mechanisms, genomic advances, and precision prevention strategiesSemantic proximity Read ↗

Low-intensity transcranial ultrasound (LITUS) exerts neuroprotective effects by modulating inflammatory responses via the Piezo1-Dkk3/Ca 2+ /PI3K-Akt signaling pathwaySemantic proximity Read ↗

TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in mammalian brainSemantic proximity Read ↗

Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity.Semantic proximity Read ↗

A Human TREK-1/HEK Cell Line: A Highly Efficient Screening Tool for Drug Development in Neurological DiseasesSemantic proximity Read ↗

Enhanced K <sub>Na</sub> 1.1 Channel Underlies Cortical Hyperexcitability and Seizure Susceptibility after Traumatic Brain InjurySemantic proximity Read ↗

Prolonged critical avalanche burial for nearly 23 hours with severe hypothermia and severe frostbite with good recovery: A case reportSemantic proximity Read ↗

Mechanistic insights into volatile anesthetic modulation of K2P channelsSemantic proximity Read ↗

Kir6.2-containing ATP-sensitive potassium channels protect cortical neurons from ischemic/anoxic injury in vitro and in vivo.Semantic proximity Read ↗

A causal role for TRESK loss of function in migraine mechanismsSemantic proximity Read ↗

Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.