Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy

Abstract excerpt

Therapeutic hypothermia (TH) is potentially an important therapy for central nervous system (CNS) trauma. However, its clinical application remains controversial, hampered by two major factors: 1) Many of the CNS injury sites, such as the optic nerve (ON), are deeply buried, preventing access for local TH. The alternative is to apply TH systemically, which significantly limits the applicable temperature range. 2)...

Topics

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• Disease Models, Animal
• Electroretinography
• Hypoxia-Inducible Factor 1, alpha Subunit
• Microscopy, Electron
• Optic Nerve
• Retinal Ganglion Cells
• Tomography, Optical Coherence
• Up-Regulation

Identifiers and source

Literature Corpus work

d1e70d7f-74e1-5ff0-a8a3-656e037d6d94

DOI

10.1101/2021.11.07.467626