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Article

Differential distribution of vitamin D receptor (VDR) gene variants and its expression in systemic lupus erythematosus.

International journal of immunogenetics - 1 Jun 2022

De Azevêdo Silva Jaqueline, de Lima Suelen Cristina, Fragoso Thiago Sotero, Cavalcanti Catarina Addobbati Jordão, Barbosa Alexandre Domingues, Borborema Maria Eduarda de Albuquerque, de Lucena Thays Maria Costa, Duarte Angela Luzia Branco Pinto, Crovella Sergio, Sandrin-Garcia Paula

Abstract excerpt

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder that displays an important genetic background. Vitamin D3 (VD3 ) through its receptor (VDR) plays an important immunomodulatory role in autoimmune misbalance, being capable of modulating immune responses. Genetic alterations in VDR gene may contribute to an altered risk in SLE development and clinical manifestations. We investigated VDR...

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PMID: 35560516
DOI: 10.1111/iji.12576

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