Article
After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes.
The American journal of pathology - 1 Apr 2010
Mancinelli Romina, Franchitto Antonio, Gaudio Eugenio, Onori Paolo, Glaser Shannon, Francis Heather, Venter Julie, Demorrow Sharon, Carpino Guido, Kopriva Shelley, White Mellanie, Fava Giammarco, Alvaro Domenico, Alpini Gianfranco
Abstract excerpt
Large cholangiocytes secrete bicarbonate in response to secretin and proliferate after bile duct ligation by activation of cyclic adenosine 3', 5'-monophosphate signaling. The Ca(2+)-dependent adenylyl cyclase 8 (AC8, expressed by large cholangiocytes) regulates secretin-induced choleresis. Ca(2+...
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