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Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation

15 Jun 2011

Abstract excerpt

Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine adenosyltransferase (MAT). MAT1A is silenced in hepatocellular carcinoma (HCC), and absence of MAT1A leads to spontaneous development of HCC in mice. Previous report correlated promoter methylation to silencing of MAT1A but definitive proof was lacking. Here we investigated the role of methylation in regulating MAT1A expression. There are...

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PMID: 21678410
DOI: 10.1002/jcp.22875

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