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DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma

13 Apr 2015

Abstract excerpt

BACKGROUND: Alcohol is a well-known risk factor for hepatocellular carcinoma (HCC), but the mechanisms underlying the alcohol-related hepatocarcinogenesis are still poorly understood. Alcohol alters the provision of methyl groups within the hepatic one-carbon metabolism, possibly inducing aberrant DNA methylation. Whether specific pathways are epigenetically regulated in alcohol-associated HCC is, however,...

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PMID: 25945129
DOI: 10.1186/s13148-015-0077-1

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