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Article

Altered methionine metabolism and global DNA methylation in liver cancer: Relationship with genomic instability and prognosis

6 Aug 2007

Abstract excerpt

Mounting evidence underlines the role of genomic hypomethylation in the generation of genomic instability (GI) and tumorigenesis, but whether DNA hypomethylation is required for hepatocellular carcinoma (HCC) development and progression remains unclear. We investigated the correlation between GI and DNA methylation, and influence of methionine metabolism deregulation on these parameters and hepatocarcinogenesis...

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PMID: 17680562
DOI: 10.1002/ijc.22940

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