Article
Endothelial nitric oxide synthase gene polymorphisms and the risk of diabetic nephropathy in type 2 diabetes mellitus.
Genetic testing and molecular biomarkers - 1 Jun 2012
Shoukry Amira, Shalaby Sally M, Abdelazim Shymaa, Abdelazim Marwa, Ramadan Ayman, Ismail Mabrouk I, Fouad Mohamed
Abstract excerpt
Endothelial dysfunction plays an important role in the pathogenesis of diabetic vascular disease, including diabetic nephropathy (DN). Endothelial nitric oxide synthase (eNOS) gene polymorphisms that affect eNOS activity are associated with endothelial dysfunction. The aim of this study was to evaluate the association of three polymorphisms of the eNOS gene (894G>T, -786T>C, and 27-bp-VNTR) with the risk of DN...
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