Article
Metal ion dependency of serine racemase from Dictyostelium discoideum.
Amino acids - 1 Oct 2012
Ito Tomokazu, Murase Hirotaka, Maekawa Motoki, Goto Masaru, Hayashi Shuhei, Saito Hajime, Maki Masatoshi, Hemmi Hisashi, Yoshimura Tohru
Abstract excerpt
D-Serine is known to act as an endogenous co-agonist of the N-methyl-D-aspartate receptor in the mammalian brain and is endogenously synthesized from L-serine by a pyridoxal 5'-phosphate-dependent enzyme, serine racemase. Though the soil-living mycetozoa Dictyostelium discoideum possesses no genes homologous to that of NMDA receptor, it contains genes encoding putative proteins relating to the D-serine...
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