Article
Role of zinc ion for catalytic activity in d-serine dehydratase from Saccharomyces cerevisiae.
The FEBS journal - 1 Feb 2012
Ito Tomokazu, Koga Kazushi, Hemmi Hisashi, Yoshimura Tohru
Abstract excerpt
d-Serine dehydratase from Saccharomyces cerevisiae (DsdSC) is a fold-type III pyridoxal 5'-phosphate-dependent enzyme catalyzing d-serine dehydration. The enzyme contains 1 mol Zn(2+) in its active site and shows a unique zinc dependence. The Zn(2+) is essential for the d-serine dehydration, but not for the α,β-elimination of β-Cl-d-alanine catalyzed as a side-reaction. The fact that dehydration of d-threonine...
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