Article
Tumor-reactive CD8+ early effector T cells identified at tumor site in primary and metastatic melanoma.
Cancer research - 1 Nov 2010
Anichini Andrea, Molla Alessandra, Vegetti Claudia, Bersani Ilaria, Zappasodi Roberta, Arienti Flavio, Ravagnani Fernando, Maurichi Andrea, Patuzzo Roberto, Santinami Mario, Pircher Hanspeter, Di Nicola Massimo, Mortarini Roberta
Abstract excerpt
CD8(+) T cells at the earliest stage of effector generation have not been identified at tumor site of melanoma patients. Such early effectors, if present, should be characterized by a specific phenotype, distinct from that expressed at later stages of the antigen-induced differentiation program, by short-lived effector cells, memory precursors, and terminal effectors. Here, we show that neoplastic tissues from...
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