Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials.

doi:10.2337/db15-0441

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Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials.

Diabetes - 1 Dec 2015

Papandonatos George D, Pan Qing, Pajewski Nicholas M, Delahanty Linda M, Peter Inga, Erar Bahar, Ahmad Shafqat, Harden Maegan, Chen Ling, Fontanillas Pierre, Wagenknecht Lynne E, Kahn Steven E, Wing Rena R, Jablonski Kathleen A, Huggins Gordon S, Knowler William C, Florez Jose C, McCaffery Jeanne M, Franks Paul W

Abstract excerpt

Clinically relevant weight loss is achievable through lifestyle modification, but unintentional weight regain is common. We investigated whether recently discovered genetic variants affect weight loss and/or weight regain during behavioral intervention. Participants at high-risk of type 2 diabetes (Diabetes Prevention Program [DPP]; N = 917/907 intervention/comparison) or with type 2 diabetes (Look AHEAD [Action...

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PMID: 26253612
DOI: 10.2337/db15-0441
PMCID: PMC4657576

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