Article
The solution structure and activation of visual arrestin studied by small-angle X-ray scattering.
European journal of biochemistry - 1 Aug 2002
Shilton Brian H, McDowell J Hugh, Smith W Clay, Hargrave Paul A
Abstract excerpt
Visual arrestin is converted from a 'basal' state to an 'activated' state by interaction with the phosphorylated C-terminus of photoactivated rhodopsin (R*), but the conformational changes in arrestin that lead to activation are unknown. Small-angle X-ray scattering (SAXS) was used to investigate the solution structure of arrestin and characterize changes attendant upon activation. Wild-type arrestin forms dimers...
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