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Article

Population genetic structure and natural selection of Plasmodium falciparum apical membrane antigen-1 in Myanmar isolates.

Malaria journal - 7 Feb 2018

Kang Jung-Mi, Lee Jinyoung, Moe Mya, Jun Hojong, Lê Hương Giang, Kim Tae Im, Thái Thị Lam, Sohn Woon-Mok, Myint Moe Kyaw, Lin Khin, Shin Ho-Joon, Kim Tong-Soo, Na Byoung-Kuk

Abstract excerpt

BACKGROUND: Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is one of leading blood stage malaria vaccine candidates. However, genetic variation and antigenic diversity identified in global PfAMA-1 are major hurdles in the development of an effective vaccine based on this antigen. In this study, genetic structure and the effect of natural selection of PfAMA-1 among Myanmar P. falciparum isolates were...

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Identifiers

PMID: 29415731
DOI: 10.1186/s12936-018-2215-7
PMCID: PMC5804060

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