Article
Comparative sequence analysis of domain I of Plasmodium falciparum apical membrane antigen 1 from Saudi Arabia and worldwide isolates.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2016
Al-Qahtani Ahmed A, Abdel-Muhsin Abdel-Muhsin A, Dajem Saad M Bin, AlSheikh Adel Ali H, Bohol Marie Fe F, Al-Ahdal Mohammed N, Putaporntip Chaturong, Jongwutiwes Somchai
Abstract excerpt
The apical membrane antigen 1 of Plasmodium falciparum (PfAMA1) plays a crucial role in erythrocyte invasion and is a target of protective antibodies. Although domain I of PfAMA1 has been considered a promising vaccine component, extensive sequence diversity in this domain could compromise an effective vaccine design. To explore the extent of sequence diversity in domain I of PfAMA1, P. falciparum-infected blood...
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