Article
GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis.
Journal of cell science - 15 Jan 2012
Wang Shuoshuo, Meyer Heiko, Ochoa-Espinosa Amanda, Buchwald Ulf, Onel Susanne, Altenhein Benjamin, Heinisch Jürgen J, Affolter Markus, Paululat Achim
Abstract excerpt
Here we report on the generation and in vivo analysis of a series of loss-of-function mutants for the Drosophila ArfGEF, Gartenzwerg. The Drosophila gene gartenzwerg (garz) encodes the orthologue of mammalian GBF1. garz is expressed ubiquitously in embryos with substantially higher abundance in cells forming diverse tubular structures such as salivary glands, trachea, proventriculus or hindgut. In the absence of...
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