The MC159 Protein from the Molluscum Contagiosum Poxvirus Inhibits NF-κB Activation by Interacting with the IκB Kinase Complex

Abstract excerpt

Molluscum contagiosum virus (MCV) causes persistent neoplasms in healthy and immunocompromised people. Its ability to persist likely is due to its arsenal of viral immunoevasion proteins. For example, the MCV MC159 protein inhibits TNF-R1-induced NF-κB activation and apoptosis. The MC159 protein is a viral FLIP and, as such, possesses two tandem death effector domains (DEDs). We show in this article that, in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Fungal Infections and Studies
• Share to Herpesvirus Infections and Treatments
• Share to Poxvirus research and outbreaks