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Inhibition of interferon gene activation by death-effector domain-containing proteins from the molluscum contagiosum virus

30 Dec 2013

Abstract excerpt

Apoptosis, NF-κB activation, and IRF3 activation are a triad of intrinsic immune responses that play crucial roles in the pathogenesis of infectious diseases, cancer, and autoimmunity. FLIPs are a family of viral and cellular proteins initially found to inhibit apoptosis and more recently to either up- or down-regulate NF-κB. As such, a broad role for FLIPs in disease regulation is postulated, but exactly how a...

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PMID: 24379396
DOI: 10.1073/pnas.1314569111

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