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Article

Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles.

PLoS pathogens - 1 Oct 2018

Hahnel Steffen R, Zdraljevic Stefan, Rodriguez Briana C, Zhao Yuehui, McGrath Patrick T, Andersen Erik C

Abstract excerpt

Benzimidazoles (BZ) are essential components of the limited chemotherapeutic arsenal available to control the global burden of parasitic nematodes. The emerging threat of BZ resistance among multiple nematode species necessitates the development of novel strategies to identify genetic and molecular mechanisms underlying this resistance. All detection of parasitic helminth resistance to BZ is focused on the...

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Identifiers

PMID: 30372484
DOI: 10.1371/journal.ppat.1007226
PMCID: PMC6224181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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