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Article

Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy.

Journal of hepatology - 1 May 2011

Lange Christian Markus, Bojunga Jörg, Ramos-Lopez Elizabeth, von Wagner Michael, Hassler Angela, Vermehren Johannes, Herrmann Eva, Badenhoop Klaus, Zeuzem Stefan, Sarrazin Christoph

Abstract excerpt

BACKGROUND & AIMS: Vitamin D is an important immune modulator and preliminary data indicated an association between vitamin D deficiency and sustained virologic response (SVR) rates in hepatitis C virus (HCV) genotype 1 patients. We, therefore, performed a comprehensive analysis on the impact of vitamin D serum levels and of genetic polymorphisms with functional relevance within the vitamin D cascade on chronic...

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Share to 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21145801
DOI: 10.1016/j.jhep.2010.08.036

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