A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C.

doi:10.1371/journal.pone.0040159

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Article

A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C.

PloS one - 1 Jan 2012

Lange Christian M, Bibert Stephanie, Kutalik Zoltan, Burgisser Philippe, Cerny Andreas, Dufour Jean-Francois, Geier Andreas, Gerlach Tilman J, Heim Markus H, Malinverni Raffaele, Negro Francesco, Regenass Stephan, Badenhoop Klaus, Bojunga Jörg, Sarrazin Christoph, Zeuzem Stefan, Müller Tobias, Berg Thomas, Bochud Pierre-Yves, Moradpour Darius

Abstract excerpt

BACKGROUND: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. METHODOLOGY/PRINCIPAL FINDINGS: Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin...

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PMID: 22808108
DOI: 10.1371/journal.pone.0040159
PMCID: PMC3395683

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