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Article

ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p.

Science (New York, N.Y.) - 16 Mar 2012

Copic Alenka, Latham Catherine F, Horlbeck Max A, D'Arcangelo Jennifer G, Miller Elizabeth A

Abstract excerpt

Eukaryotic secretory proteins exit the endoplasmic reticulum (ER) via transport vesicles generated by the essential coat protein complex II (COPII) proteins. The outer coat complex, Sec13-Sec31, forms a scaffold that is thought to enforce curvature. By exploiting yeast bypass-of-sec-thirteen (bst) mutants, where Sec13p is dispensable, we probed the relationship between a compromised COPII coat and the cellular...

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Identifiers

PMID: 22300850
DOI: 10.1126/science.1215909
PMCID: PMC3306526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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