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Article

Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish.

Developmental biology - 15 Jul 2012

Niu Xubo, Gao Chuan, Jan Lo Li, Luo Yue, Meng Chunmei, Hong Jian, Hong Wanjin, Peng Jinrong

Abstract excerpt

The Sec13-Sec31 heterotetramer serves as the outer coat in the COPII complex, which mediates protein trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus. Although it has been studied in depth in yeast and cultured cells, the role of COPII in organogenesis in a multicellular organism has not. We report here that a zebrafish sec13(sq198) mutant, which exhibits a phenotype of hypoplastic digestive...

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Identifiers

PMID: 22609279
DOI: 10.1016/j.ydbio.2012.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish.PMID 22609279Read ↗

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Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking.Semantic proximity Read ↗

Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking PathwaySemantic proximity Read ↗

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